Early Human Development
Volume 83, Issue 1 , Pages 41-46 , January 2007

Insulin-like growth factor-1 receptor expression in the placentae of diabetic and normal pregnancies

  • Abdul Rahman Hayati

      Affiliations

    • Department of Pathology, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
    • Abdul Rahman Hayati and Fook Choe Cheah contributed equally to the design of the protocol of this study and the writing of this manuscript.
  • ,
  • Fook Choe Cheah

      Affiliations

    • Department of Paediatrics, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
    • Abdul Rahman Hayati and Fook Choe Cheah contributed equally to the design of the protocol of this study and the writing of this manuscript.
  • ,
  • Ay Eeng Tan

      Affiliations

    • Department of Obstetrics and Gynaecology, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • ,
  • Geok Chin Tan

      Affiliations

    • Department of Pathology, Faculty of Medicine, Hospital Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur, Malaysia
    • Corresponding Author InformationCorresponding author. Fax: +60 3 91737340.

,Accepted 6 April 2006.

References 

  1. American Diabetes Association . Gestational diabetes mellitus. Diabetes Care. 2004;27:S88–S90
  2. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus . Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care. 2003;26:S5–S20
  3. Metzger BE, Coustan DR. Summary and recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. The Organizing Committee. Diabetes Care. 1998;21:B161–B167
  4. Kjos SL, Buchanan TA. Gestational diabetes mellitus. N Engl J Med. 1999;341:1749–1756
  5. Casey BM, Lucas MJ, Mcintire DD, Leveno KJ. Pregnancy outcomes in women with gestational diabetes compared with the general obstetric population. Obstet Gynecol. 1997;90:869–873
  6. Dang K, Homko C, Reece EA. Factors associated with fetal macrosomia in offspring of gestational diabetic women. J Matern-Fetal Med. 2000;9:114–117
  7. O'Sullivan JB, Charles D, Mahan CM, Dandrow RV. Gestational diabetes and perinatal mortality rate. Am J Obstet Gynecol. 1973;116:901–904
  8. Wood SL, Sauve R, Ross S, Brant R, Love EJ. Prediabetes and perinatal mortality. Diabetes Care. 2000;23:1752–1754
  9. Kjos SL, Leung A, Henry OA, Victor MR, Paul RH, Medearis AL. Antepartum surveillance in diabetic pregnancies: predictors of fetal distress in labor. Am J Obstet Gynecol. 1995;173:1532–1539
  10. Cooper MJ, Enderlein MA, Tarnoff H, Roge CL. Asymmetric septal hypertrophy in infants of diabetic mothers. Fetal echocardiography and the impact of maternal diabetic control. Am J Dis Child. 1992;146:226–229
  11. Vela-Huerta MM, Vargas-Origel A, Olvera-Lopez A. Asymmetrical septal hypertrophy in newborn infants of diabetic mothers. Am J Perinatol. 2000;17:89–94
  12. Sheehan PQ, Rowland TW, Shah BL, McGravey VJ, Reiter EO. Maternal diabetic control and hypertrophic cardiomyopathy in infants of diabetic mothers. Clin Pediatr (Phila). 1986;25:266–271
  13. Lauszus FF, Klebe JG, Flyvbjerg A. Macrosomia associated with maternal serum insulin-like growth factor-I and -II in diabetic pregnancy. Obstet Gynecol. 2001;97:734–741
  14. Holmes RP, Holly JM, Soothill PW. A prospective study of maternal serum insulin-like growth factor-I in pregnancies with appropriately grown or growth restricted fetuses. Br J Obstet Gynaecol. 1998;105:1273–1278
  15. Le Roith D. Seminars in medicine of the Beth Israel Deaconess Medical Center. Insulin-like growth factors. N Engl J Med. 1997;336:633–640
  16. Jones JI, Clemmons DR. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev. 1995;16:3–34
  17. Hayati AR, Cheah FC, Yong JF, Tan AE, Norizah WM. The role of serum insulin-like growth factor I (IGF-I) in neonatal outcome. J Clin Pathol. 2004;57:1299–1301
  18. Werner H, Stannard B, Bach MA, Roberts CT, LeRoith D. Regulation of insulin-like growth factor I receptor gene expression in normal and pathological states. Adv Exp Med Biol. 1991;293:263–272
  19. Hefti MA, Harder BA, Eppenberger HM, Schaub MC. Signaling pathways in cardiac myocyte hypertrophy. J Mol Cell Cardiol. 1997;29:2873–2892
  20. Fholenhag KI, Sandstrom IM, Malmlof K, Skottner AI, Nyberg FJ. Human growth hormone does not cross the placenta of the pregnant rat. Growth Regul. 1994;4:181–187
  21. Davenport ML, Clemmons DR, Miles MV, Camacho-Hubner C, D'Ercole AJ, Underwood LE. Regulation of serum insulin-like growth factor-I (IGF-I) and IGF binding proteins during rat pregnancy. Endocrinology. 1990;127:1278–1286
  22. Wang HS, Lim J, English J, Irvine L, Chard T. The concentration of insulin-like growth factor-I and insulin-like growth factor-binding protein-1 in human umbilical cord serum at delivery: relation to fetal weight. J Endocrinol. 1991;129:459–464
  23. Fang J, Furesz TC, Lurent RS, Smith CH, Fant ME. Spatial polarization of insulin-like growth factor receptors on the human syncytiotrophoblast. Pediatr Res. 1997;41:258–265
  24. Baserga R, Hongo A, Rubini M, Prisco M, Valentinis B. The IGF-I receptor in cell growth, transformation and apoptosis. Biochim Biophys Acta. 1997;1332:F105–F126
  25. Baserga R, Resnicoff M, Dews M. The IGF-I receptor and cancer. Endocrine. 1997;7:99–102
  26. Rubin R, Baserga R. Insulin-like growth factor-I receptor. Its role in cell proliferation, apoptosis, and tumorigenicity. Lab Invest. 1995;73:311–331
  27. Werner H, Le Roith D. The insulin-like growth factor-I receptor signaling pathways are important for tumorigenesis and inhibition of apoptosis. Crit Rev Oncog. 1997;8:71–92
  28. Tan AE, Norizah WM, Rahman HA, Aziz BA, Cheah FC. Umbilical artery resistance index in diabetic pregnancies: the associations with fetal outcome and neonatal septal hypertrophic cardiomyopathy. J Obstet Gynaecol Res. 2005;31:296–301
  29. Gutgesell HP, Mullins CE, Gillette PC, Speer M, Rudolph AJ, McNamara DG. Transient hypertrophic subaortic stenosis in infants of diabetic mothers. J Pediatr. 1976;89:120–125
  30. Holmes R, Porter H, Newcomb P, Holly JM, Soothill P. An immunohistochemical study of type I insulin-like growth factor receptors in the placentae of pregnancies with appropriately grown or growth restricted fetuses. Placenta. 1999;20:325–330
  31. Miller HC, Wilson HM. Macrosomia, cardiac hypertrophy, erythroblastosis, and hyperplasia of the islands of Langerhans in infants born to diabetic mothers. J Pediatr. 1943;23:251–266
  32. Miller HC. Cardiac hypertrophy in newborn infants. Yale J Biol Med. 1944;16:509–519
  33. Yan-Jun L, Tsushima T, Minei S, Sanaka M, Nagashima T, Yanagisawa K, et al. Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBP-1, -2 and -3) in diabetic pregnancy: relationship to macrosomia. Endocr J. 1996;43:221–231
  34. Rizzo G, Arduini D, Romanini C. Accelerated cardiac growth and abnormal cardiac flow in fetuses of type I diabetic mothers. Obstet Gynecol. 1992;80:369–376
  35. Rechler MM, Nissley SP. Insulin-like growth factor (IGF)/somatomedin receptor subtypes: structure, function, and relationships to insulin receptors and IGF carrier proteins. Horm Res. 1986;24:152–159
  36. Daughaday WH, Rotwein P. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr Rev. 1989;10:68–91
  37. Karl PI. Insulin-like growth factor-1 stimulates amino acid uptake by the cultured human placental trophoblast. J Cell Physiol. 1995;165:83–88
  38. Kniss DA, Shubert PJ, Zimmerman PD, Landon MB, Gabbe SG. Insulinlike growth factors. Their regulation of glucose and amino acid transport in placental trophoblasts isolated from first-trimester chorionic villi. J Reprod Med. 1994;39:249–256
  39. Nissley SP, Haskell JF, Sasaki N, De Vroede MA, Rechler MM. Insulin-like growth factor receptors. J Cell Sci Suppl. 1985;3:39–51

 The results of this study were presented at the 46th annual meeting of the European Society for Pediatric Research (ESPR) held in Siena, Italy on 31 August–3 September 2005, and was published as an abstract in Pediatric Research, August 2005, volume 58(2), page 365.

PII: S0378-3782(06)00114-9

doi: 10.1016/j.earlhumdev.2006.04.002

Early Human Development
Volume 83, Issue 1 , Pages 41-46 , January 2007