Early Human Development
Volume 82, Issue 12 , Pages 781-787 , December 2006

Benefits of maternal and donor human milk for premature infants

  • Howard Heiman

      Affiliations

    • Division of Neonatal-Perinatal Medicine, Schneider Children's Hospital at North Shore, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA
    • Tel.: +1 516 562 4665; fax: +1 516 562 4516.
    • ,
  • Richard J. Schanler

      Affiliations

    • Division of Neonatal-Perinatal Medicine, Schneider Children's Hospital at North Shore, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA
    • Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, USA
    • Corresponding Author InformationCorresponding author. Neonatal-Perinatal Medicine, North Shore University Hospital, 300 Community Drive, Manhasset, NY 11030, USA. Tel.: +1 516 562 4665; fax: +1 516 562 4516.

References 

  1. Polberger S. Quality of growth in preterm neonates fed individually fortified human milk. In:  Battaglia FC,  Pedraz C,  Sawatzki G,  Falkner F,  Doménech E,  Morán J, et al. editor. Maternal and Extrauterine Nutritional Factors. Their Influence on Fetal and Infant Growth. Madrid: Ediciones Ergon, S.A.; 1996;p. 395–403
  2. Neville MC, Keller RP, Seacat J, Casey CE, Allen JC, Archer P. Studies on human lactation. I. Within-feed and between-breast variation in selected components of human milk. Am J Clin Nutr. 1984;40:635–646
  3. Valentine CJ, Hurst NM, Schanler RJ. Hindmilk improves weight gain in low-birth-weight infants fed human milk. J Pediatr Gastroenterol Nutr. 1994;18:474–477
  4. Greer FR, McCormick A, Loker J. Changes in fat concentration of human milk during delivery by intermittent bolus and continuous mechanical pump infusion. J Pediatr. 1984;105:745–749
  5. Schanler RJ. Special methods in feeding the preterm infant. In:  Tsang RC,  Nichols BL editor. Nutrition During Infancy. Philadelphia: Hanley and Belfus; 1988;p. 314–325
  6. Weber A, Loui A, Jochum F, Bührer C, Obladen M. Breast milk from mothers of very low birthweight infants: variability in fat and protein content. Acta Pædiatr. 2001;90:772–775
  7. Wight NE. Donor human milk for preterm infants. J Perinatol. 2001;21:249–254
  8. Garza C, Hopkinson JM, Schanler RJ. Human milk banking. In:  Howell RR,  Morriss FH,  Pickering LK editor. Human Milk in Infant Nutrition and Health. Springfield, IL: Charles C. Thomas; 1986;p. 225–255
  9. Oxtoby MJ. Human immunodeficiency virus and other viruses in human milk: placing the issues in broader perspective. Pediatr Infect Dis J. 1988;7:825–835
  10. Bjorksten B, Burman LG, DeChateau P, Fredrikzon B, Gothefors L, Hernell O. Collecting and banking human milk: to heat or not to heat?. Br Med J. 1980;281:765–769
  11. Koenig A, Diniz EMA, Barbarosa SFC, Vaz FAC. Immunologic factors in human milk: the effects of gestational age and pasteurization. J Hum Lact. 2005;21:439–443
  12. Hamprecht K, Maschmann J, Muller D, Dietz K, Besenthal I, Goelz R, et al. Cytomegalovirus (CMV) inactivation in breast milk: reassessment of pasteurization and freeze–thawing. Pediatr Res. 2004;56:529–535
  13. Giorgi M, Heiman H, Codipilly C, Potak D, Schanler R. Pasteurization preserves the concentration of IL-8 in human milk. E-PAS2006:59.3850.4 2006.
  14. Goldblum RM, Dill CW, Albrecht TB, Alford ES, Garza C, Goldman AS. Rapid high-temperature treatment of human milk. J Pediatr. 1984;104:380–385
  15. Prolacta Bioscience . Processing of donor human milk. Manufacturer's materials. 2006;
  16. Atkinson SA, Bryan MH, Anderson GH. Human milk feeding in premature infants: protein, fat and carbohydrate balances in the first two weeks of life. J Pediatr. 1981;99:617–624
  17. Atkinson SA, Radde IC, Anderson GH. Macromineral balances in premature infants fed their own mothers' milk or formula. J Pediatr. 1983;102:99–106
  18. Cooper PA, Rothberg AD, Pettifor JM, Bolton KD, Devenhuis S. Growth and biochemical response of premature infants fed pooled preterm milk or special formula. J Pediatr Gastroenterol Nutr. 1984;3:749–754
  19. Kashyap S, Schulze KF, Forsyth M, Dell RB, Ramakrishnan R, Heird WC. Growth, nutrient retention, and metabolic response of low-birth-weight infants fed supplemented and unsupplemented preterm human milk. Am J Clin Nutr. 1990;52:254–262
  20. Gross SJ. Growth and biochemical response of preterm infants fed human milk or modified infant formula. N Engl J Med. 1983;308:237–241
  21. Tyson JE, Lasky RE, Mize CE, Richards CJ, Blair-Smith N, Whyte R, et al. Growth, metabolic response, and development in very-low-birth-weight infants fed banked human milk or enriched formula. I. Neonatal findings. J Pediatr. 1983;103:95–104
  22. Boyd CA, Quigley MA, Brocklehurst P. Donor breast milk versus infant formula for preterm infants: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2006;
  23. Polberger SKT, Axelsson IE, Räihä NCR. Urinary and serum urea as indicators of protein metabolism in very low birthweight infants fed varying human milk protein intakes. Acta Paediatr Scand. 1990;79:737–742
  24. Pettifor JM, Rajah R, Venter A. Bone mineralization and mineral homeostasis in very low-birth-weight infants fed either human milk or fortified human milk. J Pediatr Gastroenterol Nutr. 1989;8:217–224
  25. Rowe J, Rowe D, Horak E, Spackman T, Saltzman R, Robinson S, et al. Hypophosphatemia and hypercalciuria in small premature infants fed human milk: evidence for inadequate dietary phosphorus. J Pediatr. 1984;104:112–117
  26. Lucas A, Brooke OG, Baker BA, Bishop N, Morley R. High alkaline phosphatase activity and growth in preterm neonates. Arch Dis Child. 1989;64:902–909
  27. Fewtrell MS, Prentice A, Cole TJ, Lucas A. Effects of growth during infancy and childhood on bone mineralization and turnover in preterm children aged 8–12 years. Acta Pædiatr. 2000;89:148–153
  28. Roy RN, Chance GW, Radde IC, Hill DE, Willis DM, Sheepers J. Late hyponatremia in very low birthweight infants. Pediatr Res. 1976;10:526–531
  29. Obladen M, Loui A, Kampmann W, Renz H. Zinc deficiency in rapidly growing preterm infants. Acta Paediatr. 1998;87:685–691
  30. Narayanan I, Prakash K, Bala S, Verma RK, Gujral VV. Partial supplementation with expressed breast-milk for prevention of infection in low-birth-weight infants. Lancet. 1980;2:561–563
  31. Narayanan I, Prakash K, Murthy NS, Gujral VV. Randomised controlled trial of effect of raw and holder pasteurised human milk and of formula supplements on incidence of neonatal infection. Lancet. 1984;ii:1111–1113
  32. Lucas A, Cole TJ. Breast milk and neonatal necrotizing enterocolitis. Lancet. 1990;336:1519–1523
  33. Contreras-Lemus J, Flores-Huerta S, Cisneros-Silva I, Orozco-Vigueras H, Hernandez-Gutierrez J, Fernandez-Morales J, et al. Disminucion de la morbilidad en neonatos pretermino alimentados con leche de su propia madre. Biol Med Hosp Infant Mex. 1992;49:671–677
  34. El-Mohandes AE, Picard MB, Simmens SJ, Keiser JF. Use of human milk in the intensive care nursery decreases the incidence of nosocomial sepsis. J Perinatol. 1998;17:130–134
  35. McGuire W, Anthony MY. Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: systematic review. Arch Dis Child Fetal Neonatal Ed. 2003;88:F11–F14
  36. Schultz K, Soltesz G, Mestyan J. The metabolic consequences of human milk and formula feeding in premature infants. Acta Paediatr Scand. 1980;69:647–652
  37. Polberger SKT, Axelsson IA, Raiha NCR. Growth of very low birth weight infants on varying amounts of human milk protein. Pediatr Res. 1989;25:414–419
  38. Funkquist E, Tuvemo T, Jonsson B, Serenius F, Hedberg-Nyqvist K. Growth and breastfeeding among low birth weight infants fed with or without protein enrichment of human milk. Ups J Med Sci. 2006;111:97–108
  39. Kuschel CA, Harding JE. Protein supplementation of human milk for promoting growth in preterm infants (Cochrane Review). The Cochrane Library. 2001;
  40. Rowe JC, Wood DH, Rowe DW, Raisz LG. Nutritional hypophosphatemic rickets in a premature infant fed breast milk. N Engl J Med. 1979;300:293–296
  41. Schanler RJ, Garza C. Mineral utilization and growth of healthy preterm infants fed fortified human milk (FM) or cow milk-based formula (CM). Fed Proc. 1987;46:1015
  42. Kuschel CA, Harding JE. Multicomponent fortified human milk for promoting growth in preterm infants. The Cochrane Library. 2005;1–36
  43. Kumar SP, Sacks LM. Hyponatremia in very low-birth-weight infants and human milk feedings. J Pediatr. 1978;93:1026–1027
  44. Schanler RJ, Lau C, Hurst NM, Smith EO. Randomized trial of donor human milk versus preterm formula as substitutes for mothers' own milk in the feeding of extremely premature infants. Pediatrics. 2005;116:400–406
  45. Hylander MA, Strobino DM, Dhanireddy R. Human milk feedings and infection among very low birth weight infants. Pediatrics. 1998;102:e38
  46. Lucas A, Fewtrell MS, Morley R, Lucas PJ, Baker BA, Lister G, et al. Randomized outcome trial of human milk fortification and developmental outcome in preterm infants. Am J Clin Nutr. 1996;64:142–151
  47. Schanler RJ. Human milk fortification for premature infants. Am J Clin Nutr. 1996;64:249–250
  48. Schanler RJ, Shulman RJ, Lau C. Feeding strategies for premature infants: beneficial outcomes of feeding fortified human milk vs. preterm formula. Pediatrics. 1999;103:1150–1157
  49. Furman L, Taylor G, Minich N, Hack M. The effect of maternal milk on neonatal morbidity of very low-birth-weight infants. Arch Pediatr Adolesc Med. 2003;157:66–71
  50. Meinzen-Derr J, Poindexter BB, Donovan EF, Stoll BJ, Warner BB, Morrow A, et al. The role of human milk feedings in risk of late-onset sepsis. Pediatr Res. 2004;55:393A
  51. Ronnestad A, Abrahamsen TG, Medbo S, Reigstad H, Lossius K, Kaaresen PI, et al. Late-onset septicemia in a Norwegian national cohort of extremely premature infants receiving very early full human milk feeding. Pediatrics. 2006;115:269–276
  52. de Silva A, Jones PW, Spenser SA. Does human milk reduce infection rates in preterm infants? A systematic review. Arch Dis Child Fetal Neonatal Ed. 2004;89:F509–F513
  53. Lucas A, Cole TJ, Morley R, Lucas PJ, David JA, Bamford MF, et al. Factors associated with maternal choice to provide breast milk for low birth weight infants. Arch Dis Child. 1988;59:722–730
  54. Anderson JW, Johnstone BM, Remley DT. Breastfeeding and cognitive development: a meta-analysis. Am J Clin Nutr. 1999;70:525–535
  55. Lucas A, Morley R, Cole TJ, Lister G, Leeson-Payne C. Breast milk and subsequent intelligence quotient in children born preterm. Lancet. 1992;339:261–264
  56. Horwood LJ, Fergusson DM. Breastfeeding and later cognitive and academic outcomes. Pediatrics. 1998;101:E91–E97
  57. Horwood LJ, Mogridge N, Darlow BA. Cognitive, educational, and behavioral outcomes at 7 to 8 years in a national very low birthweight cohort. Arch Dis Child Fetal Neonatal. 1998;79:F12–F20
  58. Horwood LJ, Darlow BA, Mogridge N. Breast milk feeding and cognitive ability at 7–8 years. Arch Dis Child Fetal Neonatal. 2001;84:F23–F27
  59. O'Connor DL, Jacobs J, Hall R, Adamkin D, Auestad N, Castillo M, et al. Growth and development of premature infants fed predominantly human milk, predominantly premature infant formula, or a combination of human milk and premature formula. J Pediatr Gastroenterol Nutr. 2003;37:437–446
  60. Vohr BR, Poindexter BB, Dusick AM, McKinley LT, Wright LL, Langer JC, et al. Beneficial effects of breast milk in the neonatal intensive care unit on the developmental outcome of extremely low birth weight infants at 18 months of age. Pediatrics. 2006;118:e115–e123
  61. Hack M, Flannery DJ, Schluchter M, Cartar L, Borawski E, Klein N. Outcomes in young adulthood for very-low-birth-weight infants. N Engl J Med. 2002;346:149–157
  62. Lucas A, Morley R, Cole TJ, Gore SM. A randomised multicentre study of human milk versus formula and later development in preterm infants. Arch Dis Child. 1994;70:F141–F146
  63. Lucas A, Gore SM, Cole TJ, Bamford MF, Dossetor JFB, Barr I, et al. Multicenter trial on feeding low birthweight infants: effects of diet on early growth. Arch Dis Child. 1984;59:722–730
  64. Moody GJ, Schanler RJ, Lau C, Shulman RJ. Feeding tolerance in premature infants fed fortified human milk. J Pediatr Gastroenterol Nutr. 2000;30:408–412
  65. Barrett-Reis B, Hall RT, Schanler RJ, Berseth CL, Chan G, Ernst JA, et al. Enhanced growth of preterm infants fed a new powdered human milk fortifier: a randomized controlled trial. Pediatrics. 2000;106:581–588
  66. Porcelli P, Schanler R, Greer F, Chan G, Gross S, Mehta N, et al. Growth in human milk-fed very low birth weight infants receiving a new human milk fortifier. Ann Nutr Metab. 2000;44:2–10
  67. Berseth CL, Van Aerde JE, Gross S, Stolz SI, Haris CL, Hansen JW. Growth, efficacy, and safety of feeding an iron-fortified human milk fortifier. Pediatrics. 2004;114:e699–e706
  68. Greer FR, McCormick A. Improved bone mineralization and growth in premature infants fed fortified own mother's milk. J Pediatr. 1988;112:961–969
  69. Schanler RJ, Hurst NM, Lau C. The use of human milk and breastfeeding in premature infants. Clin Perinatol. 1999;26:379–398
  70. Ziegler EE. Breast-milk fortification. Acta Pædiatr. 2001;90:720–723

PII: S0378-3782(06)00232-5

doi: 10.1016/j.earlhumdev.2006.09.009

Early Human Development
Volume 82, Issue 12 , Pages 781-787 , December 2006

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