General movements in the perinatal period and its relation to echogenicity changes in the brain

Rosier-van Dunné, Fleur M.; van Wezel-Meijler, Gerda; Bakker, Maaike P.; de Groot, Laila; Odendaal, Hein J.; de Vries, Johanna I.

doi:10.1016/j.earlhumdev.2010.01.023

« Previous Next »Early Human Development
Volume 86, Issue 2 , Pages 83-86, February 2010

General movements in the perinatal period and its relation to echogenicity changes in the brain

Fleur M. Rosier-van Dunné
- Department of Obstetrics and Gynaecology, Research Institute MOVE, VU University Medical Center, Amsterdam, The Netherlands
- Corresponding author. Department of Obstetrics and Gynaecology, VU university Medical Center, Post box 7057, 1007MB Amsterdam, The Netherlands. Fax: +31 204441485.
Gerda van Wezel-Meijler
- Department of Neonatology, Leiden University Medical Center, Leiden, The Netherlands
Maaike P. Bakker
- Department of Obstetrics and Gynaecology, Research Institute MOVE, VU University Medical Center, Amsterdam, The Netherlands
Laila de Groot
- Department of Neonatology, Research Institute MOVE, VU University Medical Center, Amsterdam, The Netherlands
Hein J. Odendaal
- Department of Obstetrics and Gynaecology, Tygerberg Hospital, Stellenbosch University, South Africa
Johanna I. de Vries
- Department of Obstetrics and Gynaecology, Research Institute MOVE, VU University Medical Center, Amsterdam, The Netherlands

Received 6 August 2009; received in revised form 24 November 2009; accepted 19 January 2010.

Abstract

Background

In preterm born infants abnormal general movements (GMs) generally normalize before three months post term, but may persist when perinatal brain injury is present.

Aims

To assess the continuity of GM quality from fetal to early neonatal period and its relation to brain echogenicity changes.

Study design

Prospective study examining GMs and three vulnerable brain areas before and 7days after birth. The quality of GMs was classified as normal or abnormal by Gestalt-perception. The brain was examined for moderate echogenicity changes (periventricular: brighter than choroid plexus, intraventricular: filling equal or more than 50% of the ventricle, and locally increased basal ganglia/thalami).

Subjects

94 fetuses from pregnancies complicated by preterm hypertensive disorders or labour at a gestational age between 26 and 34weeks.

Outcomes measures

Correlations of fetal GMs, echogenicity changes, and clinical parameters (e.g. gestational age, parity, hypertensive disorders or preterm labour, oligohydramnios and fetal growth restriction) with neonatal GMs.

Results

Fetal GMs were abnormal in 64%, normalizing in 68% within 7days after birth. Fetal GMs were significantly related to postnatal GMs (p=0.045). Moderate fetal brain echogenicity changes and clinical parameters were not significantly related to neonatal GM.

Conclusions

In this population of pregnancies compromised by hypertensive disorders or preterm labour fetal GMs correlated with neonatal GMs. Presence of moderate echogenicity changes in the fetal brain was not related to neonatal GMs.

Keywords: Fetus, Neonate, General movements, Brain, Preterm birth, Ultrasonography