Early Human Development
Volume 86, Issue 2 , Pages 113-117 , February 2010

IL-6 and TNFα across the umbilical circulation in term pregnancies: Relationship with labour events

  • Greg Duncombe

      Affiliations

    • Department of Obstetrics and Gynaecology, Children Health Research Institute, University of Western Ontario, London, Canada
  • ,
  • Ruud A.W. Veldhuizen

      Affiliations

    • Department of Physiology and Pharmacology, Children Health Research Institute, University of Western Ontario, London, Canada
  • ,
  • Robert J. Gratton

      Affiliations

    • Department of Obstetrics and Gynaecology, Children Health Research Institute, University of Western Ontario, London, Canada
  • ,
  • Victor K.M. Han

      Affiliations

    • Department of Obstetrics and Gynaecology, Children Health Research Institute, University of Western Ontario, London, Canada
    • Department of Pediatrics, Children Health Research Institute, University of Western Ontario, London, Canada
  • ,
  • Bryan S. Richardson

      Affiliations

    • Department of Obstetrics and Gynaecology, Children Health Research Institute, University of Western Ontario, London, Canada
    • Department of Physiology and Pharmacology, Children Health Research Institute, University of Western Ontario, London, Canada
    • Department of Pediatrics, Children Health Research Institute, University of Western Ontario, London, Canada
    • Corresponding Author InformationCorresponding author. Department of Obstetrics and Gynaecology, The University of Western Ontario, 268 Grosvenor St, Room B3-041, London ON Canada N6A 4V2. Tel.: +1 519 646 6106; fax: +1 519 646 6213.

Received 9 December 2009 ,Revised 26 January 2010 ,Accepted 29 January 2010.

References 

  1. Bowen JM, Chamley L, Keelan JA, Mitchell MD. Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition. Placenta. 2002;23:257–273
  2. Keelan JA, Blumenstein M, Helliwell RJA, Sato TA, Marvin KW, Mitchell MD. Cytokines, prostaglandins and parturition — a review. Placenta. 2003;24:Suppl A, Trophoblast Res, Vol. 17, S33-S46
  3. Gotsch F, Romero R, Kusanovic JP, Mazaki-Tovi S, Pineles BL, Erez O, et al. The fetal inflammatory response syndrome. Clin Obstet Gynecol. 2007;50:652–683
  4. Christiaens I, Zaragoza DB, Guilbert L, Robertson SA, Mitchell BF, Olson DM. Inflammatory processes in preterm and term parturition. J Reprod Immunol. 2008;79:50–57
  5. Steinborn A, Von Gall C, Hildenbrand R, Stutte HJ, Kaufmann M. Identification of placental cytokine-producing cells in term and preterm labor. Obstet Gynecol. 1998;91:329–335
  6. Gomez R, Romero R, Ghezzi F, Yoon BH, Mazor M, Berry SM. The fetal inflammatory response syndrome. Am J Obstet Gynecol. 1998;179:194–202
  7. Yoon BH, Romero R, Kim KS, Park JS, Ki SH, Kim BI, et al. A systemic fetal inflammatory response and the development of bronchopulmonary dysplasia. Am J Obstet Gynecol. 1999;181:773–779
  8. Young A, Thomson AJ, Ledingham MA, Jordan F, Greer IA, Norman JE. Immunolocalization of proinflammatory cytokines in myometrium, cervix, and fetal membranes during human parturition at term. Biol Reprod. 2002;66:445–449
  9. Osman I, Young A, Ledingham MA, Thomson AJ, Jordan F, Greer IA, et al. Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Mol Hum Reprod. 2003;9:41–45
  10. Chaiworapongsa T, Romero R, Kim JC, Kim YM, Blackwell SC, Yoon BH, et al. Evidence for fetal involvement in the pathologic process of clinical chorioamnionitis. Am J Obstet Gynecol. 2002;186:1178–1182
  11. Shalak LF, Laptook AR, Jafri HS, Ramilo O, Perlman JM. Clinical chorioamnionitis, elevated cytokines, and brain injury in term infants. Pediatr. 2002;110:673–680
  12. Rogers BB, Alexander JM, Head J, McIntire D, Leveno KJ. Umbilical vein interleukin-6 levels correlate with the severity of placental inflammation and gestational age. Hum Pathol. 2002;33:335–340
  13. Pierce BT, Pierce LM, Wagner RK, Apodaca CC, Hume RF, Nielsen PE, et al. Hypoperfusion causes increased production of interleukin 6 and tumor necrosis factor α in the isolated, dually perfused placental cotyledon. Am J Obstet Gynecol. 2000;183:863–867
  14. Chiesa C, Pellegrini G, Panero A, De Luca T, Assumma M, Signore F, et al. Umbilical cord interleukin-6 levels are elevated in term neonates with perinatal asphyxia. Eur J Clin Invest. 2003;33:352–358
  15. Prout A, Frasch MG, Veldhuizen RAW, Hammond R, Ross MG, Richardson BS. Inflammatory response to repetitive umbilical cord occlusions with worsening acidosis in the near term ovine fetus. Am J Obstet Gynecol. 2010;202:82;e1–9
  16. Smulian JC, Campbell WA, Vintzileos AM, Rodis JF. Correlation between umbilical artery and vein levels of interleukin-6 and soluble intracellular adhesion molecule-1. J Matern Fetal Med. 1997;6:67–70
  17. El Maradny E, Kanayama N, Halim A, Machara K, Terao T. Stretching of fetal membranes increases the concentration of interleukin-8 and collagenase activity. Am J Obstet Gynecol. 1996;174:843–849
  18. Machara K, Kanayama N, El Maradny E, Uezato T, Fujita M, Terao T. Mechanical stretching induces interleukin-8 gene expression in fetal membranes — a possible role for the initiation of human parturition. Eur J Obstet Gynecol Reprod Biol. 1996;70:191–196
  19. Hauth JC, Gilstrap LC, Hankins GDV, Connor KD. Term maternal and neonatal complications of acute chorioamnionitis. Obstet Gynecol. 1985;66:59–62
  20. Challis JR, Lockwood CJ, Myatt L, Norman JE, Strauss JF, Petraglia F. Inflammation and pregnancy. Reprod Sci. 2009;16:206–215
  21. Trudinger B, Wang J, Athayde N, Beutler L, Wang X. Association of umbilical placental vascular disease with fetal acute inflammatory cytokine responses. J Soc Gynecol Investig. 2002;9:152–157
  22. Wang X, Athayde N, Trudinger B. Fetal plasma stimulates endothelial cell production of cytokines and the family of suppressor of cytokine signaling in umbilical placental vascular disease. Am J Obstet Gynecol. 2003;188:510–516
  23. Romero R, Gomez R, Ghezzi F, Yoon BH, Mazor M, Edwin SS, et al. A fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition. Am J Obstet Gynecol. 1998;179:186–193
  24. Van Zee KJ, Kohno T, Fischer E, Rock CS, Moldawer LL, Lowry SF. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo. Proc Natl Acad Sci U S A. 1992;89:4845–4849
  25. Lockwood CJ. Recent advances in elucidating the pathogenesis of preterm delivery, the detection of patients at risk, and preventative therapies. Curr Opin Obstet Gynecol. 1994;6:7–18
  26. Richardson BS, Czikk MJ, daSilva O, Natale R. The impact of labour at term on measures of neonatal outcome. Am J Obstet Gynecol. 2005;192:219–226
  27. Moss TJ, Newnham JP, Willett KE, Kramer BW, Jobe AH, Ikegami M. Early gestational intra-amniotic endotoxin: lung function, surfactant, and morphometry. Am J Respir Crit Care Med. 2002;165:805–811

 Umbilical cord levels for IL-6 are increased in low risk labouring patients at term without evidence of infection when compared to non-labouring patients delivered by elective cesarean section.

PII: S0378-3782(10)00038-1

doi: 10.1016/j.earlhumdev.2010.01.027

Early Human Development
Volume 86, Issue 2 , Pages 113-117 , February 2010