Early Human Development
Volume 86, Issue 2 , Pages 127-131 , February 2010

The relationship between cortisol concentrations in pregnancy and systemic vascular resistance in childhood

  • Patricia Helen Carvalho Rondó

      Affiliations

    • Nutrition Department, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo 715, São Paulo, SP, CEP-01246-904, Brazil
    • Corresponding Author InformationCorresponding author. Tel./fax: +55 11 3061 777.
    • ,
  • Jesuana Oliveira Lemos

      Affiliations

    • Nutrition Department, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo 715, São Paulo, SP, CEP-01246-904, Brazil
    • ,
  • Joilane Alves Pereira

      Affiliations

    • Nutrition Department, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo 715, São Paulo, SP, CEP-01246-904, Brazil
    • ,
  • José Maria Pacheco Souza

      Affiliations

    • Statistics and Epidemiology Department, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo 715, São Paulo, CEP-01246-904, Brazil

Received 16 July 2009 ,Revised 27 January 2010 ,Accepted 2 February 2010.

References 

  1. Seckl RS. Prenatal glucocorticoids and long-term programming. Eur J Endocrinol. 2004;151:U49–U62
  2. Benediktsson R, Calder AA, Edwards CRW, Seckl JR. Placental 11 beta-hydroxysteroid dehydrogenase: a key regulator of fetal glucocorticoid exposure. Clin Endocrinol. 1997;46:161–166
  3. Jansson T, Power TL. Role of the placenta in fetal programming: underlying mechanisms and potential interventional approaches. Clin Sci. 2007;113:1–13
  4. Kajantie E, Dunkel L, Turpeinen U, Stenman UH, Wood PJ, Nuutila M, et al. Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants. J Clin Endocrinol Metab. 2003;88:493–500
  5. Whitworth A, Williamson PM, Mangos G, Kelly JJ. Cardiovascular consequences of cortisol excess. Vasc Health Risk Manag. 2005;1:291–299
  6. Tangalakis K, Lumbers ER, Moritz KM, Towstoless MK, Wintour EM. Effect of cortisol on blood pressure and vascular reactivity in the ovine fetus. Exp Physiol. 1992;77:709–717
  7. Koenen SV, Mecenas CA, Smith GS, Jenkins S, Nathanielsz PW. Effects of maternal betamethasone administration on fetal and maternal blood pressure and heart rate in the baboon at 0.7 of gestation. Am J Obstet Gynecol. 2002;186:812–871
  8. Kari MA, Hallman M, Eronen M, Teramo K, Virtanen M, Koivisto M, et al. Prenatal dexamethasone treatment in conjunction with rescue therapy of human surfactant: a randomized placebo-controlled multicenter study. Pediatrics. 1994;93:730–736
  9. Berry LM, Polk DH, Ikegami M, Jobe AH, Padbury JF, Ervin MG. Preterm newborn lamb renal and cardiovascular responses after fetal or maternal antenatal betamethasone. Am J Physiol Regul Integr Comp Physiol. 1997;41:R1972–R1979
  10. Levitt N, Lidsay RS, Homes MC. Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat. Neuroendocrinology. 1996;64:412–418
  11. Gatford KL, Wintour EM, de Blasio MJ, Owens JA, Dodic M. Differential timing for programming of glucose homeostasis, sensitivity to insulin and blood pressure by in utero exposure to dexamethasone in sheep. Clin Sci. 2000;98:553–560
  12. Sugden MC, Langdown ML, Munns MJ, Holness MJ. Maternal glucocorticoid treatment modulates placental leptin and leptin receptor expression and materno-fetal leptin physiology during late pregnancy, and elicits hypertension associated with hyperleptinaemia in the early-growth-retarded adult offspring. Eur J Endocrinol. 2001;145:529–539
  13. Docherty C, Kalmar-Nagy J, Engelen M, Koenen SV, Nijland M, Kuc RE, et al. Effect of in vivo infusion of dexamethasone at 0.75 gestation on responses to endothelin-1 in isolated fetal ovine resistance arteries. Am J Physiol. 2001;281:R261–R268
  14. Dodic M, Baird R, Hantzis V, Koukoulas I, Moritz K, Peers A, et al. Organs/systems potentially involved in one model of programmed hypertension in sheep. Clin Exp Pharmacol Physiol. 2001;28:952–956
  15. Molnar J, Nijland MJM, Howe DC, Nathanielsz PW. Evidence for microvascular dysfunction after prenatal dexamethasone at 0.7, 0.75, and 0.8 gestation in sheep. Am J Physiol Regul Integr Comp Physiol. 2002;283:R561–R567
  16. Moritz KM, Johnson K, Douglas-Denton R, Wintour EM, Dodic M. Maternal glucocorticoid treatment programs alterations in the rennin angiotensin system of the ovine fetal kidney. Endocrinology. 2002;14:4455–4463
  17. Molnar J, Howe DC, Nijland MJ, Nathanielsz PW. Prenatal dexamethasone leads to both endothelial dysfunction and vasodilatory compensation in sheep. J Physiol. 2003;547:61–66
  18. Moritz KM, Boon WM, Wintour EM. Glucocorticoid programming of adult disease. Cell Tissue Res. 2005;322:81–88
  19. Vu TT, Hirst JJ, Stark M, Wright IM, Palliser HK, Hodyl N, et al. Changes in human placental 5alpha-reductase isoenzyme expression with advancing gestation: effects of fetal sex and glucocorticoid exposure. Reprod Fertil Dev. 2009;21:599–607
  20. Moritz KM, Dodic M, Jefferies AJ, Wintour EM, Dematteo R, Singh RR, et al. Hemodynamic characteristics of hypertension induced by prenatal cortisol exposure in sheep. Clin Exp Pharmacol Physiol. 2009;36:981–987
  21. Rondó PHC, Ferreira RF, Nogueira F, Ribeiro MC, Lobert H, Artes R. Maternal psychological stress and distress as predictors of low birth weight, prematurity and intrauterine growth retardation. Eur J Clin Nutr. 2003;57:266–272
  22. Rondó PHC, Lemos JO, Pereira JA, Oliveira JM, Innocente LR. The relationship between birthweight and arterial elasticity in childhood. Clin Sci. 2008;115:317–326
  23. Kirschbaum C, Hellhammer DH. Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology. 1994;19:313–333
  24. Rondó PHC, Vaz AJ, Moraes F, Tomkins A. The relationship between salivary cortisol concentrations and anxiety in adolescent and non-adolescent pregnant women. Braz J Med Biol Res. 2004;37:1403–1409
  25. World Health Organization — WHO. Geneva: Switzerland. Available online from http://www.who.int/bmi/index.jsp?introPage=intro_3.html. Assessed in 13th April 2009.
  26. Centers for Disease Control and Prevention — CDC and National Center for Health Statistics. Atlanta: United States of America. Available online from http://www.cdc.gov/growthcharts. Assessed in 13th April 2009.
  27. In:  Jelliffe DB,  Jelliffe EFP editor. Community nutritional assessment with special reference to less technically developed countries. 2nd edn.. Oxford University Press: London; 1989;
  28. Capurro H, Konishezky S, Fonseca D, Caldeyro-Barcia R. A simplified method for diagnosis of gestational age in the newborn infant. J Pediatr. 1978;93:120–122
  29. Cohn JN, Finkelstein S, McVeigh G, Morgan D, LeMay L, Robinson J, et al. Noninvasive pulse wave analysis for the early detection of vascular disease. Hypertension. 1995;26:503–508
  30. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents. Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: a working group report from the National High Blood Pressure Education Program. Pediatrics 1996; 98: 649–658.
  31. Baskett JJ, Lewis RR, Beasley MG, Gosling RG. Changes in carotid artery compliance with age. Age Ageing. 1990;19:241–246
  32. Dülger H, Arik M, Sekeroğlu MR, Tarakçioğlu M, Noyan T, Cesur Y, et al. Pro-inflammatory cytokines in Turkish children with protein-energy malnutrition. Mediators Inflamm. 2002;11:363–365
  33. Salvadori M, Sontrop JM, Garg AX, Truong J, Suri RS, Mahmud FH, et al. Elevated blood pressure in relation to overweight and obesity among children in a rural Canadian community. Pediatrics. 2008;122:e821–e827
  34. Ward AM, Fall CH, Stein CE, Kumaran K, Veena SR, Wood PJ, et al. Cortisol and the metabolic syndrome in South Asians. Clin Endocrinol. 2003;58:500–505
  35. Evensen L, Micklem DR, Blois A, Berge SV, Aarsaether N, Littlewood-Evans A, et al. Mural cell associated VEGF is required for organotypic vessel formation. PLoS One. 2009;4:e5798
  36. Xiao D, Huang X, Xu Z, Yang S, Zhang L. Prenatal cocaine exposure differentially causes vascular dysfunction in adult offspring. Hypertension. 2009;53:937–943
  37. Muszkat M, Kurnik D, Sofowora GG, Solus J, Xie HG, Harris PA, et al. Desensitization of vascular response in vivo: contribution of genetic variation in the [alpha]2B-adrenergic receptor subtype. J Hypertens. 2010;28:278–284
  38. Quaedackers JS, Roelfsema V, Fraser M, Gunn AJ, Bennet L. Cardiovascular and endocrine effects of a single course of maternal dexamethasone treatment in preterm fetal sheep. BJOG. 2005;112:182–191
  39. Derks JB, Giussani DA, Jenkins SL, Wentworth RA, Visser GH, Padbury JF, et al. A comparative study of cardiovascular, endocrine and behavioural effects of betamethasone and dexamethasone administration to fetal sheep. J Physiol. 1997;499:217–226
  40. Schwab M, Roedel M, Anwar MA, Müller T, Schubert H, Buchwalder LF, et al. Effects of betamethasone administration to the fetal sheep in late gestation on fetal cerebral blood flow. J Physiol. 2000;528:619–632
  41. Fletcher AJW, McGarrigle HHG, Edwards CMB, Fowden AL, Giussani DA. Effects of low dose dexamethasone treatment on basal cardiovascular and endocrine function in fetal sheep during late gestation. J Physiol. 2002;545:649–660
  42. Anwar MA, Schwab M, Poston L, Nathanielsz PW. Betamethasone-mediated vascular dysfunction and changes in hematological profile in the ovine fetus. Am J Physiol. 1999;276:H1137–H1143
  43. Moss TJ, Sloboda DM, Gurrin LC, Harding R, Challis JR, Newnham JP. Programming effects in sheep of pre-natal growth restriction and glucocorticoid exposure. Am J Physiol. 2001;281:R960–R970
  44. Moss TJ, Harding R, Newnham JP. Lung function, arterial pressure and growth in sheep during early postnatal life following single and repeated prenatal corticosteroid treatments. Early Hum Dev. 2002;66:11–24
  45. Louey S, Cock ML, Harding R. Postnatal development of arterial pressure: influence of the intrauterine environment. Arch Physiol Biochem. 2003;111:53–60
  46. Dodic M, May CN, Wintour EM, Coghlan JP. An early prenatal exposure to excess glucocorticoid leads to hypertensive offspring in sheep. Clin Sci. 1998;94:149–155
  47. Dodic M, Hantzis V, Duncan J, Rees S, Koukoulas I, Johnson K, et al. Programming effects of short prenatal exposure to cortisol. FASEB J. 2002;16:1017–1026
  48. Wintour EM, Johnson K, Koukoulas I, Moritz K, Tersteeg M, Dodic M. Programming the cardiovascular system, kidney and the brain — a review. Placenta. 2003;24:S65–S71(Suppl A)
  49. Wintour EM, Moritz KM, Johnson K, Ricardo S, Samuel CS, Dodic M. Reduced nephron number in adult sheep, hypertensive as a result of prenatal glucocorticoid treatment. J Physiol. 2003;549:929–935
  50. Dodic M, Peers A, Coghlan JP, May CN, Lumbers E, Yu Z, et al. Altered cardiovascular haemodynamics and baroreceptor-heart rate reflex in adult sheep after prenatal exposure to dexamethasone. Clin Sci. 1999;97:103–109
  51. Schwab M, Coksaygan T, Nathanielsz PW. Betamethasone effects on ovine uterine and umbilical placental perfusion at the dose used to enhance fetal lung maturation. Am J Obstet Gynecol. 2006;194:572–579
  52. Roghair RD, Lamb FS, Miller FJ, Scholz TD, Segar JL. Early gestation dexamethasone programs enhanced postnatal ovine coronary artery vascular reactivity. Am J Physiol Regul Integr Comp Physiol. 2005;288:46–53
  53. Fletcher AJ, McGarrigle HH, Edwards AL, Fowden AL, Giussani DA. Effects of low dose dexamethasone treatment on basal cardiovascular and endocrine function in fetal sheep during gestation. J Physiol. 2002;545:649–660
  54. Huch A, Huch R, Schneider H, Rooth G. Continuous transcutaneous monitoring of fetal oxygen tension during labour. Br J Obstet Gynaecol. 1977;84:1–39
  55. Peña AS, Wiltshire E, MacKenzie K, Gent R, Piotto L, Hirte C, et al. Vascular endothelial and smooth muscle function relates to body mass index and glucose in obese and nonobese children. J Clin Endocrinol Metab. 2006;91:4467–4471
  56. Ece A, Gürkan F, Celik F, Bosnak M, Yel S, Balik H, et al. Paraoxonase, total antioxidant activity and peroxide levels in marasmic children: relationship with leptin. Clin Biochem. 2007;40:634–639

PII: S0378-3782(10)00046-0

doi: 10.1016/j.earlhumdev.2010.02.002

Early Human Development
Volume 86, Issue 2 , Pages 127-131 , February 2010

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