Early Human Development
Volume 86, Issue 3 , Pages 187-191 , March 2010

Prolonged maternal magnesium administration and bone metabolism in neonates

  • Koji Yokoyama

      Affiliations

    • Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
  • ,
  • Naoto Takahashi

      Affiliations

    • Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 285 58 7366; fax: +81 285 44 6123.
  • ,
  • Yukari Yada

      Affiliations

    • Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
  • ,
  • Yasunori Koike

      Affiliations

    • Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
  • ,
  • Ryou Kawamata

      Affiliations

    • Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
  • ,
  • Ritei Uehara

      Affiliations

    • Department of Public Health, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
  • ,
  • Yumi Kono

      Affiliations

    • Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
  • ,
  • Yoko Honma

      Affiliations

    • Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan
  • ,
  • Mariko Y. Momoi

      Affiliations

    • Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1, Yakushiji, Shimotsuke, Tochigi 329-0498, Japan

Received 12 September 2009 ,Revised 17 February 2010 ,Accepted 17 February 2010.

References 

  1. Goldenberg RL. The management of preterm labor. Obstet Gynecol. 2002;100(5):1020–1037
  2. McGuinness GA, Weinstein MM, Cruikshank DP, Pitkin RM. Effects of magnesium sulfate treatment on perinatal calcium metabolism. II. Neonatal responses. Obstet Gynecol. 1980;56(5):595–600
  3. Petrie RH. Preterm parturition. Tocolysis using magnesium sulfate. Semin Perinatol. 1981;5:266–273
  4. Riaz M, Porat R, Brodsky NL, Hurt H. The effects of maternal magnesium sulfate treatment on newborns: a prospective controlled study. J Perinatol. 1998;18(6 Pt 1):449–454
  5. Taber EB, Tan L, Chao CR, Beall MH, Ross MG. Pharmacokinetics of ionized versus total magnesium in subjects with preterm labor and preeclampsia. Am J Obstet Gynecol. 2002;186:1017–1021
  6. Kosasa TS, Busse R, Wahl N, Hirata G, Nakayama RT, Hale RW. Long-term tocolysis with combined intravenous terbutaline and magnesium sulfate: a 10-year study of 1000 patients. Obstet Gynecol. 1994;84:369–373
  7. Dudley D, Gagnon D, Varner M. Long-term tocolysis with intravenous magnesium sulfate. Obstet Gynecol. 1989;73:373–378
  8. Harrison V, Fawcus S, Jordaan E. Magnesium Supplementation and perinatal hypoxia: outcome of a parallel group randomized trial in pregnancy. BJOG. 2007;114(8):994–1002
  9. Nelson KB, Grether JK. Can magnesium sulfate reduce the risk of cerebral palsy in very low birthweight infants?. Pediatrics. 1995;95:263–269
  10. Crowther CA, Hiller JE, Doyle LW, Haslam RR. Effect of magnesium sulfate given for neuroprotection before preterm birth: a randomized controlled trial. JAMA. 2003;290:2669–2676
  11. Marret S, Marpeau L, Zupan-Simunek V, Eurin D, Lévêque C, Hellt MF, et al. Magnesium sulphate given before very-preterm birth to protect infant brain: the randomized controlled PREMAG trial. BJOG. 2007;114:310–318
  12. Marret S, Marpeau L, Bénichou J. Benefit of magnesium sulfate given before very preterm birth to protect infant brain. Pediatrics. 2008;121:225–226
  13. Marret S, Marpeau L, Follet-Bouhamed C, Cambonie G, Astruc D, Delaporte B, et al. Effect of magnesium sulphate on mortality and neurologic morbidity of the very-preterm newborn with two-year neurologic outcome: results of the prospective PREMAG trial. Gynecol Obstet Fertil. 2008;362:278–288
  14. Constantine MM, Weiner SJ. Effects of antenatal exposure to magnesium sulfate on neuroprotection and mortality in preterm infants. Obstet Gynecol. 2009;114:354–364
  15. Rouse DJ, Hirtz DG, Thom E, Varner MW, Spong CY, Mercer B, et al. A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy. N Engl J Med. 2008;359:895–905
  16. Lamm CI, Norton KI, Murphy RJ, Wilkins IA, Rabinowitz JG. Congenital rickets associated with magnesium sulfate infusion for tocolysis. J Pediatr. 1988;113:1078–1082
  17. Cumming WA, Thomas VJ. Hypermagnesemia: a cause of abnormal metaphyses in the neonate. Am J Roentgenol. 1989;152:1071–1072
  18. Holcomb WL, Shackelford GD, Pitrie RH. Magnesium tocolysis and neonatal bone abnormalities: a controlled study. Obstet Gynecol. 1991;78:611–614
  19. Santi MD, Henry GW, Douglas GL. Magnesium sulfate treatment of preterm labor as a cause of abnormal neonatal bone mineralization. J Pediatr Orthop. 1994;14(2):249–253
  20. Schanler RJ, Smith LG, Burns PA. Effects of long-term maternal intravenous magnesium sulfate therapy on neonatal calcium metabolism and bone mineral content. Gynecol Obstet Invest. 1997;43:236–241
  21. Matsuda Y, Maeda Y, Ito M, Sakamoto H, Masaoka N, Takada M, et al. Effect of magnesium sulfate treatment on neonatal bone abnormalities. Gynecol Obstet Invest. 1997;44:82–88
  22. Levav AL, Chan L, Wapner RJ. Long-term magnesium sulfate tocolysis and maternal osteoporosis in triplet pregnancy: a case report. Am J Perinatol. 1998;15:43–46
  23. Malaeb SN, Rassi AI, Haddad MC, Seoud MA, Yunis KA. Bone mineralization in newborns whose mothers received magnesium sulphate for tocolysis of premature labour. Pediatr Radiol. 2004;34:384–386
  24. Tsukahara H, Kobata R, Tamura S, Mayumi M. Neonatal bone abnormalities attributable to maternal administration of magnesium sulfate. Pediatr Radiol [Letter]. 2004;34:673–674
  25. Nassar AH, Sakhel K, Maarouf H, Naassan GR, Usta IM. Adverse maternal and neonatal outcome of prolonged magnesium sulfate tocolysis. Acta Obstet Gynecol. 2006;85:1099–1103
  26. Wedig KE, Kogan J, Schorry EK, Whitsett JA. Skeletal demineralization and fractures caused by fetal magnesium toxicity. J Perinatol. 2006;26:371–374

PII: S0378-3782(10)00051-4

doi: 10.1016/j.earlhumdev.2010.02.007

Early Human Development
Volume 86, Issue 3 , Pages 187-191 , March 2010