Early Human Development
Volume 86, Issue 4 , Pages 231-236 , April 2010

A prospective study on intrauterine cannabis exposure and fetal blood flow

  • Hanan El Marroun

      Affiliations

    • The Generation R Study Group, Erasmus Medical Center (EMC), The Netherlands
    • Department of Child and Adolescent Psychiatry, EMC, Sophia Children's Hospital, The Netherlands
  • ,
  • Henning Tiemeier

      Affiliations

    • Department of Child and Adolescent Psychiatry, EMC, Sophia Children's Hospital, The Netherlands
    • Department of Epidemiology, EMC, The Netherlands
  • ,
  • Eric A.P. Steegers

      Affiliations

    • Department of Obstetrics and Gynaecology, EMC, The Netherlands
  • ,
  • Jolien W. Roos-Hesselink

      Affiliations

    • Department of Cardiology, EMC, The Netherlands
  • ,
  • Vincent W.V. Jaddoe

      Affiliations

    • The Generation R Study Group, Erasmus Medical Center (EMC), The Netherlands
    • Department of Epidemiology, EMC, The Netherlands
  • ,
  • Albert Hofman

      Affiliations

    • Department of Epidemiology, EMC, The Netherlands
  • ,
  • Frank C. Verhulst

      Affiliations

    • Department of Child and Adolescent Psychiatry, EMC, Sophia Children's Hospital, The Netherlands
  • ,
  • Wim van den Brink

      Affiliations

    • Academic Medical Center University of Amsterdam, The Netherlands
    • Amsterdam Institute for Addiction Research, The Netherlands
  • ,
  • Anja C. Huizink

      Affiliations

    • Department of Child and Adolescent Psychiatry, EMC, Sophia Children's Hospital, The Netherlands
    • University of Amsterdam, Department of Educational Sciences, The Netherlands
    • Corresponding Author InformationCorresponding author. Department of Educational Sciences, University of Amsterdam, P.O. Box 94208, 1090 GE, Amsterdam, The Netherlands. Tel.: +31 20 52 51 558; fax: +31 20 52 51 200.

Received 16 December 2009 ,Revised 30 March 2010 ,Accepted 30 March 2010.

References 

  1. European Monitoring Centre of Drugs and Drug Addiction. Annual report 2006: the state of the drugs problem in Europe. Lisbon, Portugal; 2006. Report No.: 92-9168-266-7.
  2. El Marroun H, Tiemeier H, Jaddoe VW, Hofman A, Mackenbach JP, Steegers EA, et al. Demographic, emotional and social determinants of cannabis use in early pregnancy: the Generation R study. Drug Alcohol Depend. 2008;98:218–226
  3. Ebrahim SH, Gfroerer J. Pregnancy-related substance use in the United States during 1996–1998. Obstet Gynecol. 2003;101:374–379
  4. Pijlman FT, Rigter SM, Hoek J, Goldschmidt HM, Niesink RJ. Strong increase in total delta-THC in cannabis preparations sold in Dutch coffee shops. Addict Biol. 2005;10:171–180
  5. Hillard CJ. Endocannabinoids and vascular function. J Pharmacol Exp Ther. 2000;294:27–32
  6. Kunos G, Jarai Z, Batkai S, Goparaju SK, Ishac EJ, Liu J, et al. Endocannabinoids as cardiovascular modulators. Chem Phys Lipids. 2000;108:159–168
  7. Pacher P, Batkai S, Kunos G. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev. 2006;58:389–462
  8. Little BB, VanBeveren TT. Placental transfer of selected substances of abuse. Semin Perinatol. 1996;20:147–153
  9. Vardaris RM, Weisz DJ, Fazel A, Rawitch AB. Chronic administration of delta-9-tetrahydrocannabinol to pregnant rats: studies of pup behavior and placental transfer. Pharmacol Biochem Behav. 1976;4:249–254
  10. Helliwell RJ, Chamley LW, Blake-Palmer K, Mitchell MD, Wu J, Kearn CS, et al. Characterization of the endocannabinoid system in early human pregnancy. J Clin Endocrinol Metab. 2004;89:5168–5174
  11. Beratis NG, Panagoulias D, Varvarigou A. Increased blood pressure in neonates and infants whose mothers smoked during pregnancy. J Pediatr. 1996;128:806–812
  12. Blake KV, Gurrin LC, Evans SF, Beilin LJ, Landau LI, Stanley FJ, et al. Maternal cigarette smoking during pregnancy, low birth weight and subsequent blood pressure in early childhood. Early Hum Dev. 2000;57:137–147
  13. Xiao D, Huang X, Lawrence J, Yang S, Zhang L. Fetal and neonatal nicotine exposure differentially regulates vascular contractility in adult male and female offspring. J Pharmacol Exp Ther. 2007;320:654–661
  14. Xiao D, Huang X, Yang S, Zhang L. Direct effects of nicotine on contractility of the uterine artery in pregnancy. J Pharmacol Exp Ther. 2007;322:180–185
  15. Jaddoe VW, Mackenbach JP, Moll HA, Steegers EA, Tiemeier H, Verhulst FC, et al. The Generation R Study: design and cohort profile. Eur J Epidemiol. 2006;21:475–484
  16. Verburg BO, Geelhoed JJ, Steegers EA, Hofman A, Moll HA, Witteman JC, et al. Fetal kidney volume and its association with growth and blood flow in fetal life: the Generation R Study. Kidney Int. 2007;72:754–761
  17. Hadlock FP, Deter RL, Harrist RB, Park SK. Estimating fetal age: computer-assisted analysis of multiple fetal growth parameters. Radiology. 1984;152:497–501
  18. Verburg BO, Jaddoe VW, Wladimiroff JW, Hofman A, Witteman JC, Steegers EA. Fetal hemodynamic adaptive changes related to intrauterine growth: the Generation R Study. Circulation. 2008;117:649–659
  19. Baschat AA, Hecher K. Fetal growth restriction due to placental disease. Semin Perinatol. 2004;28:67–80
  20. Boito S, Struijk PC, Ursem NT, Stijnen T, Wladimiroff JW. Umbilical venous volume flow in the normally developing and growth-restricted human fetus. Ultrasound Obstet Gynecol. 2002;19:344–349
  21. Wladimiroff JW, vd Wijngaard JA, Degani S, Noordam MJ, van Eyck J, Tonge HM. Cerebral and umbilical arterial blood flow velocity waveforms in normal and growth-retarded pregnancies. Obstet Gynecol. 1987;69:705–709
  22. Day N, Sambamoorthi U, Taylor P, Richardson G, Robles N, Jhon Y, et al. Prenatal marijuana use and neonatal outcome. Neurotoxicol Teratol. 1991;13:329–334
  23. Hurd YL, Wang X, Anderson V, Beck O, Minkoff H, Dow-Edwards D. Marijuana impairs growth in mid-gestation fetuses. Neurotoxicol Teratol. 2005;27:221–229
  24. Sherwood RA, Keating J, Kavvadia V, Greenough A, Peters TJ. Substance misuse in early pregnancy and relationship to fetal outcome. Eur J Pediatr. 1999;158:488–492
  25. El Marroun H, Tiemeier H, Steegers EA, Jaddoe VW, Hofman A, Verhulst FC, et al. Intrauterine cannabis exposure affects fetal growth trajectories: the Generation R Study. J Am Acad Child Adolesc Psych. 2009;
  26. Huizink AC, Mulder EJ. Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring. Neurosci Biobehav Rev. 2006;30:24–41
  27. Habayeb OM, Taylor AH, Evans MD, Cooke MS, Taylor DJ, Bell SC, et al. Plasma levels of the endocannabinoid anandamide in women—a potential role in pregnancy maintenance and labor?. J Clin Endocrinol Metab. 2004;89:5482–5487
  28. Maccarrone M, Bisogno T, Valensise H, Lazzarin N, Fezza F, Manna C, et al. Low fatty acid amide hydrolase and high anandamide levels are associated with failure to achieve an ongoing pregnancy after IVF and embryo transfer. Mol Hum Reprod. 2002;8:188–195
  29. O'Sullivan SE, Kendall DA, Randall MD. Further characterization of the time-dependent vascular effects of delta9-tetrahydrocannabinol. J Pharmacol Exp Ther. 2006;317:428–438
  30. Severi FM, Rizzo G, Bocchi C, D'Antona D, Verzuri MS, Arduini D. Intrauterine growth retardation and fetal cardiac function. Fetal Diagn Ther. 2000;15:8–19

PII: S0378-3782(10)00079-4

doi: 10.1016/j.earlhumdev.2010.03.006

Early Human Development
Volume 86, Issue 4 , Pages 231-236 , April 2010