Early Human Development
Volume 86, Issue 6 , Pages 351-360 , June 2010

Magnetic resonance imaging in hypoxic-ischaemic encephalopathy

  • Mary Rutherford

      Affiliations

    • Perinatal Imaging Group, Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road London W12 OHS, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44 208 383 3298; fax: +44 208 383 3038.
    • ,
  • Christina Malamateniou

      Affiliations

    • Perinatal Imaging Group, Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road London W12 OHS, United Kingdom
    • ,
  • Amy McGuinness

      Affiliations

    • Perinatal Imaging Group, Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road London W12 OHS, United Kingdom
    • ,
  • Joanna Allsop

      Affiliations

    • Perinatal Imaging Group, Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road London W12 OHS, United Kingdom
    • ,
  • Miriam Martinez Biarge

      Affiliations

    • La Paz University Hospital, Department of Neonatology, Paseo de la Castellana, 261, E-28046 Madrid, Spain
    • Tel.: +34 91 7277416; fax: +34 91 7277480.
    • ,
  • Serena Counsell

      Affiliations

    • Neonatal Medicine Group, Robert Steiner MR Unit, MRC Clinical Sciences Centre, Imperial College, Hammersmith Hospital, Du Cane Road London W12 OHS, United Kingdom
    • Tel.: +44 208 383 3298; fax: +44 208 383 3038.

References 

  1. Rutherford MA, Pennock JM, Counsell SJ, Mercuri E, Cowan FM, Dubowitz LM, et al. Abnormal magnetic resonance signal in the internal capsule predicts poor neurodevelopmental outcome in infants with hypoxic-ischemic encephalopathy. Pediatrics. 1998;102:323–328
  2. Cheong JL, Cady EB, Penrice J, Wyatt JS, Cox IJ, Robertson NJ. Proton MR spectroscopy in neonates with perinatal cerebral hypoxic-ischemic injury: metabolite peak-area ratios, relaxation times, and absolute concentrations. AJNR Am J Neuroradiol. 2006;27(7):1546–1554
  3. Jiang S, Xue H, Glover A, Rutherford M, Rueckert D, Hajnal JV. MRI of moving subjects using multislice snapshot images with volume reconstruction (SVR): application to fetal, neonatal, and adult brain studies. IEEE Trans Med Imaging. 2007;26:967–980
  4. Mercuri E, Cowan F, Rutherford M, Acolet D, Pennock J, Dubowitz L. Ischaemic and haemorrhagic brain lesions in newborns with seizures and normal Apgar scores. Arch Dis Child Fetal Neonatal Ed. 1995;73:67–74
  5. Rutherford MA, Counsell S, Allsop Joanna, Boardman James, Kapellou Olga, Larkman David, et al. Diffusion weighted MR imaging in term perinatal brain injury: a comparison with site of lesion and time from birth. Pediatrics. 2004;114(4):1004–1014
  6. Okereafor A, Allsop J, Counsell SJ, Fitzpatrick J, Azzopardi D, Rutherford MA, et al. Patterns of brain injury in neonates exposed to perinatal sentinel events. Pediatrics. 2008;121(5):906–914
  7. Logitharajah P, Rutherford MA, Cowan FM. Hypoxic-ischemic encephalopathy in preterm infants: antecedent factors, brain imaging, and outcome. Pediatr Res. 2009;66(2):222–229
  8. Burns CM, Rutherford MA, Boardman JP, Cowan FM. Patterns of cerebral injury and neurodevelopmental outcomes after symptomatic neonatal hypoglycemia. Pediatrics. 2008;122(1):65–74
  9. Rutherford M, Ramenghi LA, Edwards AD, Brocklehurst P, Halliday H, Levene M, et al. Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. Lancet Neurol. 2010;(1):39–45(Electronic publication ahead of print)
  10. Cowan F, Dubowitz L, Mercuri E, Counsell S, Rutherford M. White matter injury can lead to cognitive without major motor deficits following perinatal asphyxia and early encephalopathy. Dev Med Child Neurol Suppl. 2003;93(45):14
  11. Nicholl RM, Balasubramaniam VP, Urquhart DS, Sellathurai N, Rutherford MA. Postmortem brain MRI with selective tissue biopsy as an adjunct to autopsy following neonatal encephalopathy. Eur J Paediatr Neurol. 2007;11(3):167–174

PII: S0378-3782(10)00112-X

doi: 10.1016/j.earlhumdev.2010.05.014

Early Human Development
Volume 86, Issue 6 , Pages 351-360 , June 2010

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