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Editorial Board
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IFC
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| Foreword |
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Foreword
This Early Human Development Supplement publishes the Proceedings of the second edition of the “International Conference on Clinical Neonatology” held in Torino, Italy, from March 10th to 12th, 2011.
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Paolo Manzoni
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S1
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| Editorial |
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Probiotics use in preterm neonates: What further evidence is needed?
Over the last decade, a growing body of evidence has shed light on the role and benefits of supplemented probiotics to preterm infants in NICU.
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Paolo Manzoni,
Stefano Rizzollo,
Nestor Vain,
Michael Mostert,
Mauro Stronati,
William Tarnow-Mordi,
Daniele Farina
et al.
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S3-S4
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| Original Articles: Plenary Sessions |
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Formula milk and neurodevelopmental and cognitive outcomes: Where are we now?
Abstract: The hypothesis that nutrition during critical windows in fetal and early life can program long-term health is intriguing and has a potentially strong implication for public health and pediat...
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Giacomo Faldella,
Arianna Aceti,
Luigi Corvaglia
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S5-S8
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New cardiopulmonary resuscitation guidelines 2010: Managing the newly born in delivery room
Abstract: Most newborns are born vigorous and do not require neonatal resuscitation. However, about 10% of newborns require some type of resuscitative assistance at birth. Although the vast majority w...
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Paolo Biban,
Boris Filipovic-Grcic,
Dominique Biarent,
Paolo Manzoni
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S9-S11
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The suctioning in the delivery room debate
Abstract: Meconium aspiration syndrome (MAS) is a life threatening respiratory disorder in infants born through meconium-stained amniotic fluid (MSAF). Its obstetric and perinatal management has been ...
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Adriana M. Aguilar,
Nestor E. Vain
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S13-S15
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Hypothermia: Novel approaches for premature infants
Abstract: Hypothermia for hypoxic ischemic encephalopathy has recently permeated clinical practice for term infants. Speculation regarding a neuroprotective benefit of hypothermia for premature infant...
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Rosemary D. Higgins,
Seetha Shankaran
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S17-S18
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Hyperglycaemia in preterm neonates: What to know, what to do
Abstract: Neonatal hyperglycaemia is a frequent complication in VLBW infants during the first week of life. The more common causes include high glucose intake, stress situations such as sepsis, NEC, a...
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Marcelo H. Decaro,
Nestor E. Vain
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S19-S22
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From the lab to the bedside: The present of research, i.e. the future of neonatology
During the last decades, almost every field of neonatology has been the subject of intense investigation. Clinical, epidemiological, and imaging studies, together with experimental research have expon...
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Alessandro Borghesi,
Paolo Manzoni,
Roberta Maragliano,
Margherita Massa,
Mauro Stronati
et al.
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S23-S25
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Drug policy in Europe: Research and funding in neonates: Current challenges, future perspectives, new opportunities
Abstract: The availability of drugs for neonates is limited as evaluation is said more difficult in neonates than in older patients and adults, resulting in off-label drug use. Indeed, diseases may be...
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Evelyne Jacqz-Aigrain
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S27-S30
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Recent advances in prevention of sepsis in the premature neonates in NICU
Abstract: Sepsis-related morbidity and mortality are major problems in NICU. Preterm neonates display clinical characteristics that make them prone to infections. Due to the high frequency of severe n...
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P. Manzoni,
S. Rizzollo,
L. Decembrino,
G. Ruffinazzi,
A. Rossi Ricci,
E. Gallo,
I. Stolfi,
M. Mostert,
M. Stronati,
D. Farina
et al.
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S31-S33
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Routine Lactobacillus rhamnosus GG administration in VLBW infants: A retrospective, 6-year cohort study
Abstract: Background: In preterm neonates, use of probiotic mixtures is increasingly popular and is effective in preventing NEC, fungal colonization, and improving feeding tolerance. However, concerns...
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Paolo Manzoni,
Gianluca Lista,
Elena Gallo,
Paola Marangione,
Claudio Priolo,
Paola Fontana,
Roberta Guardione,
Daniele Farina
et al.
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S35-S38
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Erythropoietin and retinopathy of prematurity
Abstract: Erythropoietin (EPO) is a glycoprotein that regulates many functions of an organism: It stimulates the production of red blood cells and it has angiogenic and neuroprotective properties in n...
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C. Romagnoli,
M.G. Tesfagabir,
C. Giannantonio,
P. Papacci
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S39-S42
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| RSV Symposium: Debates on RSV Hot Topics |
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The multicenter Italian birth cohort study on incidence and determinants of lower respiratory tract infection hospitalization in infants at 33 weeks GA or more: Preliminary results
Abstract: Background: Respiratory syncytial virus (RSV) causes respiratory infections during the first year of life. Very premature infants have more severe diseases and also ‘late preterm infants’ ma...
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Marcello Lanari,
Fulvio Adorni,
Michela Silvestri,
Alessandra Coscia,
Massimo Musicco,
‘Italian Study Group on Risk Factors for RSV-related Hospitalization’
et al.
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S43-S46
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Are late preterm infants as susceptible to RSV infection as full term infants?
Abstract: Preterm infants are at increased risk of being rehospitalised during the first few months of life with severe respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) that ...
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Bernhard Resch,
Bosco Paes
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S47-S49
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The relationship between RSV bronchiolitis and recurrent wheeze: The chicken and the egg
Abstract: Respiratory syncytial virus bronchiolitis is the most frequent cause of infant hospitalization. RSV bronchiolitis is often followed by recurrent episodes of wheeze. Pathogenesis of RSV bronc...
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L. Bont,
O. Ramilo
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S51-S54
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Special populations: Do we need evidence from randomized controlled trials to support the need for respiratory syncytial virus prophylaxis?
Abstract: Congenital abnormalities and impaired mechanisms that govern the normal coordinated physiology of breathing, sucking, swallowing and airway clearance, place infants with underlying medical d...
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Bosco Paes,
Paolo Manzoni
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S55-S58
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| An Update On Risk Factors And Epidemiology Of Paediatric Fungal Infections |
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Antifungal prophylaxis in neonates
Abstract: Fungal-related morbidity and mortality is a major concern for most neonatal intensive care units (NICUs) worldwide. Incidence rates are increasing and might be higher than reported due to th...
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Paolo Manzoni,
Evelyne Jacqz-Aigrain,
Stefano Rizzollo,
Caterina Franco,
Mauro Stronati,
Michael Mostert,
Daniele Farina
et al.
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S59-S60
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Pharmacokinetics of antifungal agents in children
Abstract: Invasive fungal infections in immunocompromised children are common and often fatal. The first antifungal agents such as amphotericin B and fluconazole offered effective treatment, but their...
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Kevin Watt,
Daniel K. Benjamin,
Michael Cohen-Wolkowiez
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S61-S65
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Invasive mould infections in newborns and children
Abstract: Invasive mould infections represent important complications of different pediatric conditions. Epidemiology and clinical features vary according to the type of underlying conditions that det...
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Elio Castagnola,
Maura Faraci,
Francesca Fioredda,
Loredana Amoroso,
Francesco Risso,
Alessia Franceschi,
Roberto Bandettini,
Gian Michele Magnano,
Alessio Pini Prato,
Chiara Gardella,
Serena Arrigo,
Marco Gattorno,
Giorgio Piaggio,
Antonella Ciucci,
Ines Lorenzi,
Anna Loy,
Riccardo Haupt
et al.
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S67-S69
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Efficacy and safety of antifungals in pediatric patients
Abstract: Invasive fungal infections (IFIs) constitute an important cause for morbidity and mortality in immunocompromised pediatric patients . Despite substantial achievements, the prevention and tre...
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Andreas H. Groll
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S71-S74
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Invasive candidiasis in neonates and children
Abstract: Invasive candidiasis is associated with high morbidity and mortality in neonates and children. The incidence of invasive candidiasis is greater in children than in adults and is particularly...
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Emmanuel Roilides
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S75-S76
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| Summary Of Papers Presented At Nurse Session |
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Neonatal transport: A review of the current evidence
The “Neonatal Emergency Transport Service” is the transfer of a sick baby in circumstances in which he will need access to neonatal care not available at the point of delivery.
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Hubert Messner
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S77
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Outcome of critically ill baby: Nursing aspects about the stabilization at birth
Recent advances in neonatology have led to remarkable results, in terms of survival, also for Low Birth Weight (LBW) and low gestational age infants. At the same time, new issues related to their poor...
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D. Pisano
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S79-S80
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The ‘broken’ attachment between parents and preterm infant: How and when to intervene
When premature birth occurs, a disruption of the biological maturation of a child takes place. In addition, the premature birth represents a stressful experience for the parents of the infant, especia...
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P. Sannino,
L. Plevani,
E. Bezze,
C. Cornalba
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S81-S82
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Medical and nursing care in post-operative period to the newborn with surgical problems and intestinal ostomy
Intestinal ostomies are used in situations in which there is required bowel diversion or decompression. In newborn, this happens in surgical conditions like necrotizing enterocolitis, Hirschsprung dis...
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Maristella Celegato,
Paolo Gancia
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S83
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Nurses' ethical problems in the care of extremely low birth weight infants
The progress of perinatal care technologies has decreased the mortality rate of extremely low birth weight infants (ELBW) , but has opened the question of the quality of life and growth of these prema...
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Roberta Guardione,
Elena Boano,
Pasquale Di Maio,
Alessia Catarinella,
Cristina Romano
et al.
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S85-S86
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Care procedures for healthy term newborn in maternity ward: The “open” nursery
Since the beginning of time, women needed and wanted their babies close to them. In their arms following birth, and while resting or sleeping, women kept their babies safe, warm, and nourished. Years ...
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Luigi Memo,
Germana Longo,
Patrizia Soriani
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S87-S88
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| Selected Abstracts |
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Comparison of conventional blood culture method and BacT/Alert system with respect to yield and time to positivity in neonatal sepsis
Efficient and faster ways of diagnosing neonatal sepsis than conventional blood culture are needed in clinical practice. Recently, automated systems have been developed to address this issue.
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Arti Maria,
Sumitha Phalgun,
Charoo Hans,
N. Dubey,
Deepak Goyal
et al.
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S89
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Safety of aqueous chlorhexidine gluconate for skin antisepsis in VLBW infants
No guidelines are available for antisepsis in infants with age <2months. The aim of this study is to evaluate the efficacy and safety of aqueous chlorhexidine gluconate (aCG) at different concentra...
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Maria Grazia Capretti,
Marica Spinelli,
Elisabetta Tridapalli,
Santo Arcuri,
Anna Malavolti,
Emanuela Callea,
Giacomo Faldella
et al.
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S89
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Post-natal CMV infection via mother's milk in ELBW infants born to CMV seropositive mothers
There are no widely accepted recommendations about breastfeeding premature infants born to CMV-seropositive mothers at this moment. To assess the risk of post-natal cytomegalovirus (CMV) transmission ...
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Maria Grazia Capretti,
Marica Spinelli,
Marcello Lanari,
Tiziana Lazzarotto,
Liliana Gabrielli,
Angela Chiereghin,
Evangelia Petrisli,
Giulia Piccirilli,
Elisabetta Tridapalli,
Giacomo Faldella
et al.
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S89-S90
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Neonatal screening program for haemoglobinopathies in Friuli Venezia Giulia (North-east Italy): The first Italian experience
Background: Haemoglobinopathies are the most frequent genetic disease worldwide, affecting over than 330,000newborns/year (83% sickle cell disorders and 17% thalassaemias). Till some years ago sub-Sah...
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L. De Zen,
F. Zanolli,
E. Testa,
R. Catapano,
R. Dall'Amico
et al.
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S90
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Newborn screening program for haemoglobinopathies in Haiti
Background: Data about sickle cell anemia in Haiti are very limited and often based on studies involving children of Haitian descent living in the States. From these reports, based on a little number ...
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L. De Zen,
F. Zanolli,
G. Arty,
J.E. Aupong,
R. Catalano,
R. Dall'Amico
et al.
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S90
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Can UNGAL detected at birth be a good predictor of a hemodynamically significant PDA?
There is a lack of non-invasive parameters that reflect the consequences of a hemodynamically significant PDA. We aimed to investigate whether urinary neutrophil gelatinase-associated lipocalin (UNGAL...
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Silvia Galletti,
Anna Maria Malavolti,
Giulia Aquilano,
Silvia Vandini,
Marica Spinelli,
Giacomo Faldella
et al.
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S90-S91
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The creamatocrit, lipid concentration and caloric density in mother's milk
The objective of this study was to estimate creamatocrit, calories, fats in colostrum, transitional milk, mature milk in the morning and at night in women after preterm and term births.
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Bozena Kociszewska-Najman,
Beata Borek-Dzieciol,
Ewa Sanczyk
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S91
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Efficacy of Micafungin in very low birth weight (VLBW) neonates affected by Candida parapsilosis sepsis
The incidence of invasive fungal infections is in constant growth, also due to the increasing number of neonates at risk in the NICUs. Among all fungi, Candida spp is the main cause of high morbidity ...
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L. Le Pera,
S. Cecchi,
C. Coviello,
M. Casucci,
S. Nappini,
A. Rossetti,
F. Bagnoli
et al.
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S91
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Lutein and zeaxanthin supplementation in preterm VLBW neonates in NICU: A multicentre RCT
Background: Preterm infants are at high risk of oxidative stress-induced damage, including severe multifactorial diseases such as ROP, NEC and BPD. Human milk feeding of preterms is speculated to prot...
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Paolo Manzoni,
Roberta Guardione,
Paolo Bonetti,
Claudio Priolo,
Andrea Maestri,
Caterina Mansoldo,
Michael Mostert,
Giovanni Anselmetti,
Massimo Bellettato,
Paolo Biban,
Daniele Farina
et al.
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S91-S92
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Bovine lactoferrin supplementation for prevention of necrotizing enterocolitis in preterm very-low-birth-weight neonates: A randomized trial
Context: NEC is a common and severe complication in premature neonates, particularly those with very-low-birth-weight (VLBW, <1500g at birth). Probiotics including Lactobacillus rhamnosus GG (LGG) ...
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Paolo Manzoni,
Matteo Rinaldi,
Mike Meyer,
Stefano Rizzollo,
Elena Gallo,
Silvia Cattani,
Lorenza Pugni,
Fabio Mosca,
Mario Giovanni Romeo,
Maria Pasqua Betta,
Federica Vagnarelli,
Fabrizio Ferrari,
Michele Quercia,
Nicola Laforgia,
Hubert Messner,
Roberto Pedicino,
Livia Renzullo,
Luigi Memo,
Ilaria Stolfi,
Mauro Stronati,
Maule Simona,
Michael Mostert,
Farina Daniele
et al.
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S92
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Bovine lactoferrin supplementation prevents invasive fungal infections in preterm VLBW neonates: Data from a multicenter, randomized, double-blind, placebo-controlled study
Background: Lactoferrin is a milk glycoprotein involved in innate immune host defences. In animal models, its activity is enhanced by the probiotic Lactobacillus rhamnosus GG (LGG). Data from a multic...
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P. Manzoni,
I. Stolfi,
S. Cattani,
H. Messner,
N. Laforgia,
M.G. Romeo,
L. Decembrino,
M. Rinaldi,
E. Gallo,
M. Stronati,
D. Farina
et al.
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S92-S93
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Respiratory syncytial virus (RSV) infection and congenital syndromes: A report of two cases
RSV, the most important cause of lower respiratory infections in infants, is associated with increased morbidity in risk patients. Passive protection with palivizumab yields a reduction in hospitalisa...
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Eugenia Maranella,
Giulia Zorzi,
Maria Rita Sabatini,
Paolo Candelotti,
Annamaria Bianchi,
Avenali Stefano,
Carlucci Antonio
et al.
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S93
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Survey of Italian neonatologists knowledge regarding awareness of ethanol use during pregnancy and the diagnosis of FAS and FASD
There are no Italian statistics on ethanol consumption during pregnancy. Usually, gestational drinking habit is investigated by generic questions included in the maternal interviews at prenatal visits...
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L. Memo,
L. Tarani,
R. Spoletini,
R. Pacifici,
R. Di Giovannandrea,
F. Vagnarelli,
A. Pierantozzi,
S. Pichini
et al.
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S93-S94
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Counselling in NICU… on the doctor's side!
The doctor–patient relationship has changed so much in the last years. Caring for a sick person today means to reduce the burden of ailment while considering the patient's perceptions on his own healt...
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C. Pannacciulli,
L. Esposito
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S94
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Late-onset neonatal infection caused by group B Streptococcus in late preterm
Background: Group B Streptococcus (GBS) is a major cause of severe systemic infections among the newborn. Early-onset sepsis appears in the first 3days of life and late-onset sepsis occurs from day 7 ...
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M. Bedetta,
A. Fabiano,
K. Bressan,
S. Picone,
P. Paolillo
et al.
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S94-S95
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Early-onset sepsis and inborn errors of metabolism
Background: Early-onset neonatal bacterial infections continue to be a major cause of morbidity and mortality in the newborn. The frequency of early-onset neonatal sepsis without prophylaxis is 1–5/10...
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A. Fabiano,
S. Picone,
M. Bedetta,
C. Cazzaniga,
P. Paolillo
et al.
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S95-S96
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Correlation between clinical and chest ultrasound findings in infants with bronchiolitis: A preliminary study
The chest ultrasound (CU) of bronchiolitis (B) in infants can reveal under the pleura focal or diffuse interstitial infiltrations (Ii) with/without minimal alveolar consolidations or microatelectasis ...
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Egisto Scalini,
Vincenzo Basile,
Ignazio Lofù,
Teresa De Bellis,
Maria Fortunato,
Francesca Laforgia,
Vincenzo Muolo,
Mariangela Rubino,
Rosa Salerno,
Maria Silletti,
Mariano Manzionna
et al.
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S96
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The impact of a DHA enriched diet on breast milk composition
It is well documented that docosahexaenoic acid (DHA) plays a key role in the fetal and neonatal neural development. The amount of DHA in human milk is influenced by maternal diet. Previously we have ...
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F. Scopesi,
M.G. Calevo,
F.M. Risso,
A. Sannia,
F. Traverso,
M. Bruschettini,
G. Serra
et al.
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S96
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Type III laryngotracheal cleft in a patient with suspicion of Canavan disease: A case report
Our case is a female newborn delivered at term of pregnancy. She presented with an enlarged head (39cm) and floppiness. Family history was positive for Canavan disease. We noted hypersalivation which ...
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Roberta Maragliano,
Simona Zanette,
Rita Cabano,
Francesca Garofoli,
Micol Angelini,
Alessandra Rossi Ricci,
Giulia Ruffinazzi,
Gabriele Rulfi,
Silvia Magrassi,
Mauro Stronati
et al.
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S96-S97
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Miniaturized IFN-γ assay for the diagnosis of congenital toxoplasmosis
Introduction: The diagnosis of congenital Toxoplasmosis is possible only in about 80% of cases. For several years, our laboratory has been performing immunologic tests in addition to traditional serol...
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Alessandra Rossi Ricci,
Lina Bollani,
Micol Angelini,
Roberta Maragliano,
Giulia Ruffinazzi,
Chryssoula Tzialla,
Iolanda Mazzucchelli,
Stefania Longo,
Valeria Meroni,
Mauro Stronati
et al.
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S97
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Impact of autoimmune disease on pregnancy and neonatal outcome: Our experience
Introduction: Multiple studies document the potential adverse consequences of maternal autoimmune disease on the fetus and newborn due to the transplacental passage of maternal antibodies, even in the...
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Giulia Ruffinazzi,
Lidia Decembrino,
Roberta Maragliano,
Alessandra Rossi Ricci,
Fausta Beneventi,
Veronique Ramoni,
Nunzia Decembrino,
Micol Angelini,
Arsenio Spinillo,
Mauro Stronati
et al.
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S97
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History of neonatology in the U.S. Armed Forces
The U.S. military comprises a constantly evolving population and geography with unique medical needs.
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Timothy Vedder
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S98
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If foetus can hear the external sounds, are we able to reproduce the same sounds for a preterm newborn?
Background: Early in our intrauterine life the auditive system completes his maturation. Beginning from 5 months of gestation, foetus can distinctly hear the acoustic world wrapping him in mother's wo...
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Mauro Vivalda,
Germano Dealessandri,
Marco Fringuelllino,
Giovanni B. Brero,
Daniele Farina
et al.
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S98
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The use of Lactobacillus paracasei in Bell's stage 2 of necrotizing enterocolitis in very low birth weight infants: Preliminary report
Probiotics are used for the prevention of necrotizing enterocolitis (NEC) because of their positive effects on modulation of inflammatory response and mucosal barrier function. The aim of this study w...
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Nicola Zampieri,
Angelo Pietrobelli,
Francesco Camoglio
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S98
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Necrotizing enterocolitis in multiple gestations: Comparison with singletons
NEC is one of the most important surgical disease in the first few days after birth. The aim of this study is to describe incidence of Necrotizing enterocolitis in multiple gestations compared with si...
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Nicola Zampieri,
Angelo Pietrobelli,
Carla Zamboni,
Francesco Camoglio
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S99
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